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Effects of ε4 on Object Recognition in the Non-Demented Elderly

[ Vol. 3 , Issue. 2 ]

Author(s):

Gwendolen E. Haley, Frederique Berteau-Pavy, Byung Park and Jacob Raber   Pages 127 - 137 ( 11 )

Abstract:


Previously we reported that Apolipoprotein E (ApoE) ε4 negatively affects performance in the novel-image-novel- location (NINL) object recognition test in healthy non-demented elderly human study participants. In this study, the participants were invited to return for testing sessions 6 and 18 months after the baseline session. Using a longitudinal study design, effects of ε4 on NINL test performance were assessed in study “dropouts”, participants that did not return for the second and/or third session(s), and “finishers”, participants that returned for all sessions. There were effects of ε4 on dropout rates and NINL total scores as well as sub-scores in both dropouts and finishers. NINL total score was a predictor of ε4 participant dropout. Compared to non-ε4 dropouts, ε4 dropouts had lower NINL scores. In contrast, ε4 finishers had higher NINL scores than non-ε4 finishers. Thus, the NINL test could be a valuable tool in detecting preclinical signs of age-related cognitive impairments, particularly those associated with ε4 risk.

Keywords:

ApoE, object recognition, aging, cortisol, testosterone, humans

Affiliation:

Department of Behavioral Neuroscience at OHSU, 3181 SW Sam Jackson Pkwy, Mail Code L470, Portland, OR 97239, USA



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