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Effects of ε4 on Object Recognition in the Non-Demented Elderly

[ Vol. 3 , Issue. 2 ]


Gwendolen E. Haley, Frederique Berteau-Pavy, Byung Park and Jacob Raber   Pages 127 - 137 ( 11 )


Previously we reported that Apolipoprotein E (ApoE) ε4 negatively affects performance in the novel-image-novel- location (NINL) object recognition test in healthy non-demented elderly human study participants. In this study, the participants were invited to return for testing sessions 6 and 18 months after the baseline session. Using a longitudinal study design, effects of ε4 on NINL test performance were assessed in study “dropouts”, participants that did not return for the second and/or third session(s), and “finishers”, participants that returned for all sessions. There were effects of ε4 on dropout rates and NINL total scores as well as sub-scores in both dropouts and finishers. NINL total score was a predictor of ε4 participant dropout. Compared to non-ε4 dropouts, ε4 dropouts had lower NINL scores. In contrast, ε4 finishers had higher NINL scores than non-ε4 finishers. Thus, the NINL test could be a valuable tool in detecting preclinical signs of age-related cognitive impairments, particularly those associated with ε4 risk.


ApoE, object recognition, aging, cortisol, testosterone, humans


Department of Behavioral Neuroscience at OHSU, 3181 SW Sam Jackson Pkwy, Mail Code L470, Portland, OR 97239, USA

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