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Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes

[ Vol. 11 , Issue. 2 ]

Author(s):

Alessandra B. Lopes*, Larissa B. Lopes, Roseli N. da Silveira Antunes, Josianne T. Fukasawa, Débora de A. Cavaretto and Zamir Calamita   Pages 118 - 125 ( 8 )

Abstract:


Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.

Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.

Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.

Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.

Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.

Keywords:

Immunosenescence, aging, neutrophils, lymphocytes, CD11b, CD40.

Affiliation:

Postgraduate Program in Health and Aging, Marilia School of Medicine - FAMEMA, Rua Monte Carmelo, 800, Fragata, CEP: 17519-030, Marilia - SP, Discipline of Hematology and Hemotherapy of the Federal University of Sao Paulo - UNIFESP, Rua Doutor Diogo de Faria, 824, Vila Clementino, CEP: 04037-002, Sao Paulo - SP, Discipline of Hematology and Hemotherapy of the School of Medicine of Marilia - FAMEMA. Rua Monte Carmelo, 800, Fragata, CEP: 17519-030, Marilia - SP, Laboratory of Flow Cytometry, Blood Center of Marilia Medical School - FAMEMA. Rua Lourival Freire, 240, Fragata, CEP: 17519-050, Marilia - SP, Laboratory of Flow Cytometry, Blood Center of Marilia Medical School - FAMEMA. Rua Lourival Freire, 240, Fragata, CEP: 17519-050, Marilia - SP, Discipline of Clinical Immunopathology and Allergy of the School of Medicine of Marilia - FAMEMA. Rua Monte Car-melo, 800, Fragata, CEP: 17519-030, Marilia - SP

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