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Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells

[ Vol. 8 , Issue. 3 ]

Author(s):

Kazuo Yudoh, Rie Karasawa and Junji Ishikawa   Pages 256 - 258 ( 3 )

Abstract:


Sirtuin 2, which is mainly present in cytoplasm, plays an important role in mammalian development, caloric restriction, metabolic regulation cellular antioxidant potential and the regulation of aging. We found that the protein level of sirtuin 2 in human peripheral blood mononuclear cells (PBMCs) decreases with an advance in donor age in men and women. Our data suggest that sirtuin 2 level in PBMCs decreases with age in both men and women and may have a potential as a useful biomarker monitoring health conditions and aging.

Keywords:

Age-related disease, aging, biomarker, healthy condition, peripheral blood mononuclear cells, physical activity, sirtuin 2, sirtuins.

Affiliation:

Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8512, Japan.



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